Welcome to the SIRT1 resource and FAQ page!
I will attempt to keep this page up-to-date with any new information that becomes public regarding SIRT1. If you have any links that you would like me to post on the page please send me an email and I will add them.
wiki links:
http://en.wikipedia.org/wiki/SIRT1
http://en.wikipedia.org/wiki/Sir2
http://en.wikipedia.org/wiki/Sirtuin
PLoS ONE - Public Library of Science:
SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001759
Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001571
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0002020
SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001710
SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000017
Sirtris Pharmaceuticals links & information:
SIRT1 Explanation
http://www.sirtrispharma.com/discovery-sirt1.html
News & Publications
http://www.sirtrispharma.com/news.html
Sirtris Pharma Press Releases
http://www.sirtrispharma.com/news-press.html
Sirtris Pharma Publications
http://www.sirtrispharma.com/news-pubs.html
Research Reports:
Mechanism of Human SIRT1 Activation by Resveratrol*
J. Biol. Chem., Vol. 280, Issue 17, 17187-17195, April 29, 2005
Margie T. Borra, Brian C. Smith, and John M. Denu
http://www.jbc.org/cgi/content/abstract/280/17/17187
Androgen Insensitive Prostate Cancer Stopped With SIRT1 Gene
November 30, 2006
http://www.futurepundit.com/archives/003926.html
Mitochondria, Diabetes, Dementia and SIRT1
By Benjamin V. Treadwell, Ph. D.
Juvenon Health Journal, Vol 3, #8, August 2004
http://juvenon.com/jhj/vol3no08.htm
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Nature 450, 712-716 (29 November 2007)
http://www.nature.com/nature/journal/v450/n7170/full/nature06261.html
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