A new study completed by researchers at the National Cancer Institute (NCI) that was published in the September 15th, 2008 issue of Molecular Cancer Research has shown that the increased expression of SiRT1 causes resistance when used with Cisplatin, a chemotherapy drug.
Researchers found the resistance increase as the amount of Cisplatin dosage was increased. This resistance makes the drug ineffective in its use. By learning the cause of the resistance factor scientists can research ways to lessen these effects and increase the benefits of chemotherapy using Cisplatin.
A link to the study press release can be found here:
Study Provides Clues about How Cancer Cells Develop Resistance to Chemotherapy Drug
Reference: Liang X, Finkel T, Shen D, Yin J, Aszalos A., and Gottesman MM. SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism. Molecular Cancer Research. September, 15, 2008.
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